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    49ers vs Buccaneers Week 6 Preview: Egbuka’s Rise, QB Uncertainty, and Red-Zone Chess

    49ers vs Buccaneers Week 6 at Levi’s Stadium: Egbuka’s breakout, Mac Jones injury update, and the red-zone chess match that could decide it.

    Kickoff: Sunday, Oct. 12, 2025 — Levi’s® Stadium, 1:25 pm PT

    The Setup

    The San Francisco 49ers and Tampa Bay Buccaneers both enter Week 6 at 4–1. Kyle Shanahan’s offense is searching for rhythm amid quarterback uncertainty, while Todd Bowles’ Buccaneers have found a passing spark with rookie wideout Emeka Egbuka. Both defenses travel, both offenses have red-zone questions, and the result could shape the NFC playoff picture.

    QB Situation: What It Means for the Script

    Brock Purdy is out. Mac Jones is questionable; if he can’t go, rookie Adrian Martinez steps in. With Jones, expect the full Shanahan menu—motion, play-action, in-breakers, and Y-choice to stress linebackers. With Martinez, look for a streamlined plan: quicker reads, boots, and defined throws to keep the offense on schedule.

    Egbuka’s Emergence

    Emeka Egbuka has become Tampa Bay’s key receiver with the veterans banged up. He’s producing at all levels—explosive shots, intermediate digs, and efficient chain-movers. His presence forces two things for San Francisco: respect the vertical threat and protect the seams, which can open space for Tampa’s backs and tight ends underneath.

    Where the Numbers Point

    • Offensive EPA/play: Buccaneers top-10; 49ers mid-pack.
    • Defensive EPA/play: 49ers top-10; Buccaneers around league average.
    • Pass vs Run: Tampa’s offense is pass-driven; San Francisco’s run defense is a strength while the SF run game has been inconsistent.
    • Red Zone TD%: Both teams have lagged; finishing drives is a known issue.
    • Protection: 49ers allow a low sack rate; Tampa’s pass rush is solid but not overwhelming.

    Translation: Tampa needs Baker Mayfield to keep the air game efficient—especially with Egbuka dictating coverage. San Francisco likely leans on play-action and intermediate throws, then supplements with perimeter runs and screens rather than pounding into Tampa’s interior.

    Key Matchups

    • Emeka Egbuka vs 49ers secondary: Limit explosives while still rallying to underneath throws. Bracket and safety leverage decisions will matter.
    • 49ers OL vs Vita Vea and the interior: SF’s low sack rate has to hold; the run game needs perimeter answers and angles rather than straight-ahead.
    • Warner/Greenlaw vs quick game: Tampa will hunt hook/curl windows, glance routes, and option concepts—linebacker discipline is central.

    Red Zone & Explosives Decide It

    Both teams have created yards between the 20s yet sputtered at the goal line. This sets up a game where one or two explosives and one extra red-zone conversion become the difference. For SF, play-action crossers and shot plays can flip the field. For TB, Egbuka’s gravity creates strike opportunities and DPI risk downfield.

    Prediction: Slight Edge San Francisco

    If Mac Jones plays, lean 49ers in a one-score game. Their defensive balance and pass protection should carry enough drives to outlast Tampa. If Jones sits and Martinez starts, volatility increases and the Bucs’ Mayfield-to-Egbuka connection becomes a real swing factor.

    Internal & External Links

    More 49ers Coverage on NinersRadar |
    Emeka Egbuka Player Profile

    Questions Fans Are Asking

    • Will Mac Jones suit up or does Adrian Martinez get the start for San Francisco?
    • How do the 49ers limit Emeka Egbuka without giving up easy underneath throws?
    • Can either team fix its red-zone touchdown rate this week?
    • Which side hits the explosive pass that flips field position and decides the game?

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